Standard
Lymphocyte percentage of white cells
near S1PR1 · rs77046277
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Lymphocyte percentage of white cells — no copies of the reported risk allele.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lymphocyte percentage of white cells.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lymphocyte percentage of white cells compared to the general population.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ,
Elding H,
Jiang T,
Allen D,
Ruklisa D,
Mann AL,
Mead D,
Bouman H,
Riveros-Mckay F,
Kostadima MA,
Lambourne JJ,
Sivapalaratnam S
and 62 more — show all
Downes K,
Kundu K,
Bomba L,
Berentsen K,
Bradley JR,
Daugherty LC,
Delaneau O,
Freson K,
Garner SF,
Grassi L,
Guerrero J,
Haimel M,
Janssen-Megens EM,
Kaan A,
Kamat M,
Kim B,
Mandoli A,
Marchini J,
Martens JHA,
Meacham S,
Megy K,
O'Connell J,
Petersen R,
Sharifi N,
Sheard SM,
Staley JR,
Tuna S,
van der Ent M,
Walter K,
Wang SY,
Wheeler E,
Wilder SP,
Iotchkova V,
Moore C,
Sambrook J,
Stunnenberg HG,
Di Angelantonio E,
Kaptoge S,
Kuijpers TW,
Carrillo-de-Santa-Pau E,
Juan D,
Rico D,
Valencia A,
Chen L,
Ge B,
Vasquez L,
Kwan T,
Garrido-Martín D,
Watt S,
Yang Y,
Guigo R,
Beck S,
Paul DS,
Pastinen T,
Bujold D,
Bourque G,
Frontini M,
Danesh J,
Roberts DJ,
Ouwehand WH,
Butterworth AS,
Soranzo N
Cell · 2016 · PMID 27863252 · open access
Questions about rs77046277
What is rs77046277?
rs77046277 is a single position in the genome, in or near the near S1PR1 gene. Published research associates it with lymphocyte percentage of white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs77046277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77046277 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants