LYSMD1 · rs77018356
Where this position leads
Condition: HBV-Related Hepatocellular Carcinoma
What the study found
Who was studied 977 African ancestry cases, 120,676 African ancestry controls, 630 Hispanic or Latin American cases, 59,146 Hispanic or Latin American controls, 7,355 East Asian ancestry cases, 629,454 East Asian ancestry controls, 8,216 European ancestry cases, 1,558,609 European ancestry controls, 519 cases, 347,798 controls.
The effect Each copy of the C allele shifted the measure 0.011 higher (95% confidence interval 0.0063-0.0157); p = 1 × 10−6.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 1, band 1q21.3 — in an intron of LYSMD1.
rs77018356 is a single position in the genome, in or near the LYSMD1 gene. Published research associates it with hepatocellular carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to HBV-Related Hepatocellular Carcinoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, HGG advances 2026, PMID:42357869. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hepatocellular carcinoma (rs77018356). MyGeneLog™. https://www.mygenelog.com/variants/rs77018356