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Who was studied 2,466 Black/admixed ancestry individuals; replicated in up to 1,653 European, Hispanic, Asian or Black individuals.
The effect
Each copy of the A allele shifted the measure 0.762 lower (95% confidence interval 0.56-0.96); p = 5 × 10−14.
Where it sits Chromosome 18, band 18q12.1 — a missense change in TTR.
What each result means
A/ATwo copies of the version the research linked to Metabolite peak levels (QI722). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Metabolite peak levels (QI722). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Metabolite peak levels (QI722). This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35995766 · open access
Questions about rs76992529
What is rs76992529?
rs76992529 is a single position in the genome, in or near the TTR gene. Published research associates it with metabolite peak levels (qi722). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76992529 linked to?
On MyGeneLog this position is linked to Transthyretin Amyloidosis (ATTR). The research behind each link, and its sources, are set out on that condition page.
Does rs76992529 affect how medicines work?
TTR carries pharmacogenomic findings for Acoramidis (Attruby), Tafamidis (Vyndaqel, Vyndamax), Vutrisiran (Amvuttra). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs76992529 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76992529 come from?
GWAS Catalog, Nature communications 2022, PMID:35995766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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