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Diastolic blood pressure

LEF1 · rs7694643

Where this position leads

Condition: Blood Pressure

rs7694643 Condition: Blood Pressure Blood Pressure Condition rs7694643 rs7694643 LEF1

What the study found

Who was studied 526,001 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.136 lower (95% confidence interval 0.094-0.179); p = 3 × 10−10.

Where it sits Chromosome 4, band 4q25 — in an intron of LEF1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diastolic blood pressure compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diastolic blood pressure.
G/G Published research associates this genotype with typical/baseline likelihood of Diastolic blood pressure — no copies of the reported risk allele.
Source
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study
Plotnikov D, Huang Y, Khawaja AP, Foster PJ, Zhu Z, Guggenheim JA, He M
Investigative ophthalmology & visual science · 2022 · PMID 35762941 · open access

Questions about rs7694643

What is rs7694643?

rs7694643 is a single position in the genome, in or near the LEF1 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7694643 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs7694643 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7694643 come from?

GWAS Catalog, Investigative ophthalmology & visual science 2022, PMID:35762941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diastolic blood pressure (rs7694643). MyGeneLog™. https://www.mygenelog.com/variants/rs7694643

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