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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0895 lower (95% confidence interval 0.067-0.112); p = 2 × 10−15.
How common The G allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of APOE.
What each result means
G/GTwo copies of the version the research linked to Triglyceride levels (UKB data field 30870). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Triglyceride levels (UKB data field 30870). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Triglyceride levels (UKB data field 30870). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs769451
What is rs769451?
rs769451 is a single position in the genome, in or near the APOE gene. Published research associates it with triglyceride levels (ukb data field 30870). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs769451 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs769451 affect how medicines work?
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs769451 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs769451 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Triglyceride levels (UKB data field 30870) (rs769451). MyGeneLog™. https://www.mygenelog.com/variants/rs769451