APOE · rs769450
Where this position leads
Condition: Alzheimer's Disease
What the study found
Who was studied 952 European ancestry male cases, 1,789 European ancestry female cases, 6,337 European ancestry male controls, 8,402 European ancestry female controls.
The effect Each copy of the G allele carried 1.60 times the odds of Alzheimer's disease (95% confidence interval 1.44-1.75); p = 6 × 10−19.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of APOE.
What ClinVar records
Classification
drug response for Warfarin response; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2010-08-31.
ClinVar record 619952 NM_000041.4(APOE):c.43+520G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs769450 is a single position in the genome, in or near the APOE gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Alzheimers Res Ther 2019, PMID:30636644. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease (rs769450). MyGeneLog™. https://www.mygenelog.com/variants/rs769450