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Cerebrospinal T-tau levels

APOE · rs769449

Where this position leads

Drug: Lecanemab and other anti-amyloid antibodies

rs769449 Drug: Lecanemab and other anti-amyloid antibodies Lecanemab and other anti-amyloid an… Drug rs769449 rs769449 APOE

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cerebrospinal T-tau levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cerebrospinal T-tau levels.
G/G Published research associates this genotype with typical/baseline likelihood of Cerebrospinal T-tau levels — no copies of the reported risk allele.
Source
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B
and 32 more — show all
Howells B, Huang KL, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O'Brien R, Riemenschneider M, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Schellenberg G, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Peskind ER, Li G, Di Narzo AF, Kauwe JS, Goate AM, Cruchaga C
Alzheimer’s Disease Neuroimaging Initiative (ADNI) · Alzheimer Disease Genetic Consortium (ADGC)
Acta neuropathologica · 2017 · PMID 28247064

Questions about rs769449

What is rs769449?

rs769449 is a single position in the genome, in or near the APOE gene. Published research associates it with cerebrospinal t-tau levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs769449 affect how medicines work?

APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs769449 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs769449 come from?

GWAS Catalog, Acta Neuropathol 2017, PMID:28247064. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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