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Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.039 higher (95% confidence interval 0.028-0.05); p = 1 × 10−11.
How common The T allele had a frequency of about 88% in the people studied.
Where it sits Chromosome 19, band 19p13.11 — in a regulatory region of ABHD8.
What each result means
C/CNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs76919404
What is rs76919404?
rs76919404 is a single position in the genome, in or near the ABHD8 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76919404 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs76919404 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76919404 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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