Standard
Chronic lymphocytic leukemia
LEF1 · rs7690934
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic lymphocytic leukemia compared to the general population. (GWAS Catalog, Nat Commun 2017, PMID:28165464)
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic lymphocytic leukemia. (GWAS Catalog, Nat Commun 2017, PMID:28165464)
T/T
Published research associates this genotype with typical/baseline likelihood of Chronic lymphocytic leukemia — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2017, PMID:28165464)
Source
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Law PJ,
Berndt SI,
Speedy HE,
Camp NJ,
Sava GP,
Skibola CF,
Holroyd A,
Joseph V,
Sunter NJ,
Nieters A,
Bea S,
Monnereau A
and 85 more — show all
Martin-Garcia D,
Goldin LR,
Clot G,
Teras LR,
Quintela I,
Birmann BM,
Jayne S,
Cozen W,
Majid A,
Smedby KE,
Lan Q,
Dearden C,
Brooks-Wilson AR,
Hall AG,
Purdue MP,
Mainou-Fowler T,
Vajdic CM,
Jackson GH,
Cocco P,
Marr H,
Zhang Y,
Zheng T,
Giles GG,
Lawrence C,
Call TG,
Liebow M,
Melbye M,
Glimelius B,
Mansouri L,
Glenn M,
Curtin K,
Diver WR,
Link BK,
Conde L,
Bracci PM,
Holly EA,
Jackson RD,
Tinker LF,
Benavente Y,
Boffetta P,
Brennan P,
Maynadie M,
McKay J,
Albanes D,
Weinstein S,
Wang Z,
Caporaso NE,
Morton LM,
Severson RK,
Riboli E,
Vineis P,
Vermeulen RC,
Southey MC,
Milne RL,
Clavel J,
Topka S,
Spinelli JJ,
Kraft P,
Ennas MG,
Summerfield G,
Ferri GM,
Harris RJ,
Miligi L,
Pettitt AR,
North KE,
Allsup DJ,
Fraumeni JF,
Bailey JR,
Offit K,
Pratt G,
Hjalgrim H,
Pepper C,
Chanock SJ,
Fegan C,
Rosenquist R,
de Sanjose S,
Carracedo A,
Dyer MJ,
Catovsky D,
Campo E,
Cerhan JR,
Allan JM,
Rothman N,
Houlston R,
Slager S
Nature communications · 2017 · PMID 28165464 · open access
Questions about rs7690934
What is rs7690934?
rs7690934 is a single position in the genome, in or near the LEF1 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7690934 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7690934 come from?
GWAS Catalog, Nat Commun 2017, PMID:28165464. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants