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Sensitive

Parkinson's disease

LRRK2 · rs76904798

Where this position leads

Condition: Parkinson's Disease

rs76904798 Condition: Parkinson's Disease Parkinson's Disease Condition rs76904798 rs76904798 LRRK2

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Parkinson's disease — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Parkinson's disease.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Parkinson's disease compared to the general population.
Source
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF
and 35 more — show all
Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB
International Parkinson's Disease Genomics Consortium (IPDGC) · Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI) · 23andMe · GenePD · NeuroGenetics Research Consortium (NGRC) · Hussman Institute of Human Genomics (HIHG) · Ashkenazi Jewish Dataset Investigator · Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE) · North American Brain Expression Consortium (NABEC) · United Kingdom Brain Expression Consortium (UKBEC) · Greek Parkinson's Disease Consortium · Alzheimer Genetic Analysis Group
Nature genetics · 2014 · PMID 25064009 · open access

What people read about alongside this

Brain and memory1 Sleep and insomnia1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs76904798

What is rs76904798?

rs76904798 is a single position in the genome, in or near the LRRK2 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76904798 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs76904798?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs76904798 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76904798 come from?

GWAS Catalog, Nat Genet 2014, PMID:25064009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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