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Who was studied 6,189 European ancestry cases, 931,046 European ancestry controls; replicated in 280 Norwegian ancestry cases, 69,141 Norwegian ancestry controls.
The effect
Each copy of the T allele carried 1.21 times the odds of Sick sinus syndrome (95% confidence interval 1.15-1.26); p = 2 × 10−15.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 4, band 4q25 — between genes, 1.2 kb from LINC01438.
What each result means
G/GNo copy of the version the research linked to Sick sinus syndrome. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Sick sinus syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Sick sinus syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
European heart journal · 2021 · PMID 33580673 · open access
Questions about rs7689774
What is rs7689774?
rs7689774 is a single position in the genome, in or near the PITX2 gene. Published research associates it with sick sinus syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7689774 linked to?
On MyGeneLog this position is linked to Sick Sinus Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs7689774 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7689774 come from?
GWAS Catalog, Eur Heart J 2021, PMID:33580673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2817123212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others12Total28Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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