Gene Knowledge Graph
UTC
Standard

Self-reported math ability

near SPIRE2 · rs76888998

Where this position leads

Condition: Educational Attainment

rs76888998 Condition: Educational Attainment Educational Attainment Condition rs76888998 rs76888998 near SPIRE2

What the study found

Who was studied 564,698 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0308 lower (95% confidence interval 0.024-0.038); p = 1 × 10−17.

How common The G allele had a frequency of about 92% in the people studied.

Where it sits Chromosome 16, band 16q24.3 — between genes, 0.3 kb from SPIRE2.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Self-reported math ability compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Self-reported math ability.
T/T Published research associates this genotype with typical/baseline likelihood of Self-reported math ability — no copies of the reported risk allele.
Source
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T
and 65 more — show all
Lee C, Li H, Li R, Royer R, Timshel PN, Walters RK, Willoughby EA, Yengo L, Alver M, Bao Y, Clark DW, Day FR, Furlotte NA, Joshi PK, Kemper KE, Kleinman A, Langenberg C, Mägi R, Trampush JW, Verma SS, Wu Y, Lam M, Zhao JH, Zheng Z, Boardman JD, Campbell H, Freese J, Harris KM, Hayward C, Herd P, Kumari M, Lencz T, Luan J, Malhotra AK, Metspalu A, Milani L, Ong KK, Perry JRB, Porteous DJ, Ritchie MD, Smart MC, Smith BH, Tung JY, Wareham NJ, Wilson JF, Beauchamp JP, Conley DC, Esko T, Lehrer SF, Magnusson PKE, Oskarsson S, Pers TH, Robinson MR, Thom K, Watson C, Chabris CF, Meyer MN, Laibson DI, Yang J, Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D
23andMe Research Team · COGENT (Cognitive Genomics Consortium) · Social Science Genetic Association Consortium
Nature genetics · 2018 · PMID 30038396

Questions about rs76888998

What is rs76888998?

rs76888998 is a single position in the genome, in or near the near SPIRE2 gene. Published research associates it with self-reported math ability. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76888998 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs76888998 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76888998 come from?

GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Self-reported math ability (rs76888998). MyGeneLog™. https://www.mygenelog.com/variants/rs76888998

← See all variants