near HLA-A · rs76828548
Where this position leads
Condition: Systemic Lupus Erythematosus
Strength of the evidence
Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls.
The effect Each copy of the T allele shifted the measure 0.179 higher (95% confidence interval 0.11-0.24); p = 4 × 10−8.
rs76828548 is a single position in the genome, in or near the near HLA-A gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Systemic lupus erythematosus (rs76828548). MyGeneLog™. https://www.mygenelog.com/variants/rs76828548