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Sensitive

Metabolic syndrome

near RALYL · rs76822696

Where this position leads

Condition: Metabolic Syndrome

rs76822696 Condition: Metabolic Syndrome Metabolic Syndrome Condition rs76822696 rs76822696 near RALYL

What the study found

Who was studied 720 Sub-Saharan African ancestry cases, 881 Sub-Saharan African ancestry controls.

The effect Each copy of the A allele carried 1.59 times the odds of Metabolic syndrome (95% confidence interval 1.43-1.75); p = 7 × 10−9.

How common The A allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 8, band 8q21.2 — between genes, 145.2 kb from TPM3P3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Metabolic syndrome compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Metabolic syndrome.
C/C Published research associates this genotype with typical/baseline likelihood of Metabolic syndrome — no copies of the reported risk allele.
Source
Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome
Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, Chen G, Zhou J, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K
and 5 more — show all
Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN
Molecular genetics and metabolism · 2015 · PMID 26507551

Questions about rs76822696

What is rs76822696?

rs76822696 is a single position in the genome, in or near the near RALYL gene. Published research associates it with metabolic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76822696 linked to?

On MyGeneLog this position is linked to Metabolic Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs76822696 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76822696 come from?

GWAS Catalog, Molecular genetics and metabolism 2015, PMID:26507551. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Metabolic syndrome (rs76822696). MyGeneLog™. https://www.mygenelog.com/variants/rs76822696

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