Gene Knowledge Graph
UTC
Standard

Fibrinogen

FGG · rs7681423

Where this position leads

Conditions: Venous Thromboembolism, Fibrinogen and Blood Clotting

rs7681423 Condition: Venous Thromboembolism Venous Thromboembolism Condition Condition: Fibrinogen and Blood Clotting Fibrinogen and Blood Clotting Condition rs7681423 rs7681423 FGG

What the study found

Who was studied 3,042 individuals.

The effect Each copy of the T allele shifted the measure 0.29 g/L lower (95% confidence interval 0.26-0.32); p = 1 × 10−109.

How common The T allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 4, band 4q32.1 — between genes, 5.3 kb from LOC124900169.

What each result means

C/C No copy of the version the research linked to Fibrinogen. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Fibrinogen. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Fibrinogen. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease
Lovely RS, Yang Q, Massaro JM, Wang J, D'Agostino RB Sr, O'Donnell CJ, Shannon J, Farrell DH
Arteriosclerosis, thrombosis, and vascular biology · 2011 · PMID 21757653

Questions about rs7681423

What is rs7681423?

rs7681423 is a single position in the genome, in or near the FGG gene. Published research associates it with fibrinogen. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7681423 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism, Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

Does having rs7681423 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7681423 come from?

GWAS Catalog, Arterioscler Thromb Vasc Biol 2011, PMID:21757653. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fibrinogen (rs7681423). MyGeneLog™. https://www.mygenelog.com/variants/rs7681423

← See all variants