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LGMN protein levels

RIN3 · rs76688721

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.247 higher (95% confidence interval 0.18-0.31); p = 3 × 10−15.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — in an intron of RIN3.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of LGMN protein levels — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LGMN protein levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LGMN protein levels compared to the general population.
Source

Questions about rs76688721

What is rs76688721?

rs76688721 is a single position in the genome, in or near the RIN3 gene. Published research associates it with lgmn protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs76688721 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76688721 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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LGMN protein levels (rs76688721). MyGeneLog™. https://www.mygenelog.com/variants/rs76688721

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