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Its strongest genetic-study result is p = 10−13, with 18 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the T allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 2 × 10−13.
Where it sits Chromosome 10, band 10p15.1 — in an intron of AKR1C4.
What each result means
G/GNo copy of the version the research linked to Concentration of chylomicrons and extremely large VLDL particles. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Concentration of chylomicrons and extremely large VLDL particles. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Concentration of chylomicrons and extremely large VLDL particles. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs76669111
What is rs76669111?
rs76669111 is a single position in the genome, in or near the AKR1C4 gene. Published research associates it with concentration of chylomicrons and extremely large vldl particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76669111 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs76669111 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76669111 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Concentration of chylomicrons and extremely large VLDL particles (rs76669111). MyGeneLog™. https://www.mygenelog.com/variants/rs76669111