PTPN11 · rs76662479
Where this position leads
Condition: Blood Pressure
What the study found
Who was studied 526,001 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.438 lower (95% confidence interval 0.33-0.55); p = 2 × 10−14.
Where it sits Chromosome 12, band 12q24.13 — in an intron of PTPN11.
What ClinVar records
Classification
Likely benign for Sarcoma; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2018-06-16.
ClinVar record 1198173 NM_002834.5(PTPN11):c.*32+267C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs76662479 is a single position in the genome, in or near the PTPN11 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Investigative ophthalmology & visual science 2022, PMID:35762941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Diastolic blood pressure (rs76662479). MyGeneLog™. https://www.mygenelog.com/variants/rs76662479