Standard

MRC1 protein levels

GCNT4 · rs76636990

Where this position leads

Condition: Celiac Disease

rs76636990 Condition: Celiac Disease Celiac Disease Condition rs76636990 rs76636990 GCNT4

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.188 higher (95% confidence interval 0.16-0.21); p = 2 × 10−50.

How common The A allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 5, band 5q13.3 — in an intron of GCNT4.

What each result means

A/A Two copies of the version the research linked to MRC1 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to MRC1 protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to MRC1 protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs76636990

What is rs76636990?

rs76636990 is a single position in the genome, in or near the GCNT4 gene. Published research associates it with mrc1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76636990 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs76636990 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76636990 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

MRC1 protein levels (rs76636990). MyGeneLog™. https://www.mygenelog.com/variants/rs76636990

← See all variants