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Neoplasm of uncertain behavior of male genital organs (PheCode 187.8)

CDC14A · rs766342104

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 205 African American or Afro-Caribbean cases, 104,425 African American or Afro-Caribbean controls, 594 European ancestry cases, 415,675 European ancestry controls.

The effect Each copy of the G allele shifted the measure 2.33 lower (95% confidence interval 2.28-2.38); p = 2 × 10−11.

How common The G allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 1, band 1p21.2 — in an intron of CDC14A.

What each result means

A/A No copy of the version the research linked to Neoplasm of uncertain behavior of male genital organs (PheCode 187.8). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Neoplasm of uncertain behavior of male genital organs (PheCode 187.8). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Neoplasm of uncertain behavior of male genital organs (PheCode 187.8). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs766342104

What is rs766342104?

rs766342104 is a single position in the genome, in or near the CDC14A gene. Published research associates it with neoplasm of uncertain behavior of male genital organs (phecode 187.8). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs766342104 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs766342104 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neoplasm of uncertain behavior of male genital organs (PheCode 187.8) (rs766342104). MyGeneLog™. https://www.mygenelog.com/variants/rs766342104

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