Sensitive

Nonalcoholic fatty liver disease

MTTP · rs7661964

Where this position leads

Condition: Nonalcoholic Fatty Liver Disease (NAFLD)

rs7661964 Condition: Nonalcoholic Fatty Liver Disease (NAFLD) Nonalcoholic Fatty Liver Disease (NAFLD) Condition rs7661964 rs7661964 MTTP

What the study found

Who was studied 691,479 European ancestry, African American or Afro-Caribbean, East Asian ancestry, Hispanic or Latin American, South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 7 z score higher; p = 3 × 10−12.

How common The A allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 4, band 4q23 — in an intron of MTTP.

What each result means

A/A Two copies of the version the research linked to Nonalcoholic fatty liver disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Nonalcoholic fatty liver disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Nonalcoholic fatty liver disease. This is the starting point the study compared everyone against.
Source

Questions about rs7661964

What is rs7661964?

rs7661964 is a single position in the genome, in or near the MTTP gene. Published research associates it with nonalcoholic fatty liver disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7661964 linked to?

On MyGeneLog this position is linked to Nonalcoholic Fatty Liver Disease (NAFLD). The research behind each link, and its sources, are set out on that condition page.

Does having rs7661964 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7661964 come from?

GWAS Catalog, Nature genetics 2023, PMID:37709864. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Nonalcoholic fatty liver disease (rs7661964). MyGeneLog™. https://www.mygenelog.com/variants/rs7661964

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