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Total testosterone levels

near HEPH · rs766102865

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 95,184 European ancestry males, 27,521 African American or Afro-Caribbean males, 13,443 Admixed American ancestry males, 1,836 East Asian ancestry males.

The effect Each copy of the C allele shifted the measure 0.298 higher (95% confidence interval 0.21-0.39); p = 2 × 10⁻¹⁰.

Where it sits Chromosome X, band Xq12 — between genes, 26.7 kb from HEPH.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total testosterone levels compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total testosterone levels.

T/T Published research associates this genotype with typical/baseline likelihood of Total testosterone levels — no copies of the reported risk allele.

Source

Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men

Pagadala MS, Teerlink CC, Jasuja GK, Palnati M, Anglin-Foote T, Chang NN, Deka R, Lee KM, Agiri FY, Amariuta T, Seibert TM, Rose BS

and 5 more — show all

Pridgen KM, Lynch JA, Carter HK, Panizzon MS, Hauger RL

Nature communications · 2025 · PMID 40316537 · open access

Questions about rs766102865

What is rs766102865?

rs766102865 is a single position in the genome, in or near the near HEPH gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs766102865 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs766102865 come from?

GWAS Catalog, Nature communications 2025, PMID:40316537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total testosterone levels (rs766102865). MyGeneLog™. https://www.mygenelog.com/variants/rs766102865

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