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Folate-deficiency anemia (PheCode 281.13)

near VDAC1P12 · rs765132976

Where this position leads

Condition: Folate-deficiency Anemia

rs765132976 Condition: Folate-deficiency Anemia Folate-deficiency Anemia Condition rs765132976 rs765132976 near VDAC1P12

What the study found

Who was studied 450 African American or Afro-Caribbean cases, 120,910 African American or Afro-Caribbean controls, 903 European ancestry cases, 449,159 European ancestry controls.

The effect Each copy of the T allele shifted the measure 3.35 lower (95% confidence interval 3.32-3.37); p = 6 × 10−14.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 13, band 13q13.2 — between genes, 55.8 kb from VDAC1P12.

What each result means

C/C No copy of the version the research linked to Folate-deficiency anemia (PheCode 281.13). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Folate-deficiency anemia (PheCode 281.13). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Folate-deficiency anemia (PheCode 281.13). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs765132976

What is rs765132976?

rs765132976 is a single position in the genome, in or near the near VDAC1P12 gene. Published research associates it with folate-deficiency anemia (phecode 281.13). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs765132976 linked to?

On MyGeneLog this position is linked to Folate-deficiency Anemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs765132976 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs765132976 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Folate-deficiency anemia (PheCode 281.13) (rs765132976). MyGeneLog™. https://www.mygenelog.com/variants/rs765132976

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