Standard
Menopause (age at onset)
MCM8 · rs76498344
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Menopause (age at onset) compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Menopause (age at onset).
T/T
Published research associates this genotype with typical/baseline likelihood of Menopause (age at onset) — no copies of the reported risk allele.
Source
Elucidating the genetic architecture of reproductive ageing in the Japanese population
Horikoshi M,
Day FR,
Akiyama M,
Hirata M,
Kamatani Y,
Matsuda K,
Ishigaki K,
Kanai M,
Wright H,
Toro CA,
Ojeda SR,
Lomniczi A
and 3 more — show all
Nature communications · 2018 · PMID 29773799 · open access
Questions about rs76498344
What is rs76498344?
rs76498344 is a single position in the genome, in or near the MCM8 gene. Published research associates it with menopause (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs76498344 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76498344 come from?
GWAS Catalog, Nat Commun 2018, PMID:29773799. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants