Sensitive

Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke

ZBTB46 · rs76484331

Where this position leads

Condition: Ischaemic Stroke

rs76484331 Condition: Ischaemic Stroke Ischaemic Stroke Condition rs76484331 rs76484331 ZBTB46

What the study found

Who was studied 71 European ancestry cases, 1,253 European ancestry controls; replicated in 70 European ancestry cases, 510 European ancestry controls.

The effect Each copy of the A allele carried 5.84 times the odds of Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke (95% confidence interval 3.16-10.76); p = 2 × 10−8.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 20, band 20q13.33 — in an intron of ZBTB46.

What each result means

A/A Two copies of the version the research linked to Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke. That is a smaller link than two copies.
C/C No copy of the version the research linked to Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke. This is the starting point the study compared everyone against.
Source

Questions about rs76484331

What is rs76484331?

rs76484331 is a single position in the genome, in or near the ZBTB46 gene. Published research associates it with parenchymal hematoma in thrombolytic-treated acute ischaemic stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76484331 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs76484331 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76484331 come from?

GWAS Catalog, Brain : a journal of neurology 2021, PMID:33723576. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Parenchymal hematoma in thrombolytic-treated acute ischaemic stroke (rs76484331). MyGeneLog™. https://www.mygenelog.com/variants/rs76484331

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