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Major depressive disorder

C3orf70 · rs7647854

Where this position leads

Condition: Major Depressive Disorder

rs7647854 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs7647854 rs7647854 C3orf70

What the study found

Who was studied 3,869 European ancestry 50% oldest-onset cases, 5,051 European ancestry cases, 2,691 European ancestry controls, 6,828 unknown controls; replicated in 6,107 European ancestry, Han Chinese ancestry and unknown ancestry 50% oldest-onset cases, 7,131 European ancestry, Han Chinese ancestry and unknown ancestry cases, 104,402 European ancestry controls, 5,537 Han Chinese ancestry controls, 14,291 unknown ancestry controls.

The effect Each copy of the G allele carried 1.16 times the odds of Major depressive disorder (95% confidence interval 1.11-1.21); p = 5 × 10−11.

How common The G allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 3, band 3q27.2 — between genes, 3.9 kb from EHHADH-AS1.

What each result means

A/A No copy of the version the research linked to Major depressive disorder. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Major depressive disorder. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Power RA, Tansey KE, Buttenschøn HN, Cohen-Woods S, Bigdeli T, Hall LS, Kutalik Z, Lee SH, Ripke S, Steinberg S, Teumer A, Viktorin A
and 64 more — show all
Wray NR, Arolt V, Baune BT, Boomsma DI, Børglum AD, Byrne EM, Castelao E, Craddock N, Craig IW, Dannlowski U, Deary IJ, Degenhardt F, Forstner AJ, Gordon SD, Grabe HJ, Grove J, Hamilton SP, Hayward C, Heath AC, Hocking LJ, Homuth G, Hottenga JJ, Kloiber S, Krogh J, Landén M, Lang M, Levinson DF, Lichtenstein P, Lucae S, MacIntyre DJ, Madden P, Magnusson PKE, Martin NG, McIntosh AM, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nyholt DR, Oskarsson H, Owen MJ, Padmanabhan S, Penninx BWJH, Pergadia ML, Porteous DJ, Potash JB, Preisig M, Rivera M, Shi J, Shyn SI, Sigurdsson E, Smit JH, Smith BH, Stefansson H, Stefansson K, Strohmaier J, Sullivan PF, Thomson P, Thorgeirsson TE, Van der Auwera S, Weissman MM, Breen G, Lewis CM
CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium
Biological psychiatry · 2017 · PMID 27519822 · open access

Questions about rs7647854

What is rs7647854?

rs7647854 is a single position in the genome, in or near the C3orf70 gene. Published research associates it with major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7647854 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs7647854 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7647854 come from?

GWAS Catalog, Biol Psychiatry 2016, PMID:27519822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Major depressive disorder (rs7647854). MyGeneLog™. https://www.mygenelog.com/variants/rs7647854

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