Gene Knowledge Graph
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Sensitive

Major depressive disorder

C3orf70 · rs7647854

Where this position leads

Condition: Major Depressive Disorder

rs7647854 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs7647854 rs7647854 C3orf70

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Major depressive disorder — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Major depressive disorder.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Major depressive disorder compared to the general population.
Source
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Power RA, Tansey KE, Buttenschøn HN, Cohen-Woods S, Bigdeli T, Hall LS, Kutalik Z, Lee SH, Ripke S, Steinberg S, Teumer A, Viktorin A
and 64 more — show all
Wray NR, Arolt V, Baune BT, Boomsma DI, Børglum AD, Byrne EM, Castelao E, Craddock N, Craig IW, Dannlowski U, Deary IJ, Degenhardt F, Forstner AJ, Gordon SD, Grabe HJ, Grove J, Hamilton SP, Hayward C, Heath AC, Hocking LJ, Homuth G, Hottenga JJ, Kloiber S, Krogh J, Landén M, Lang M, Levinson DF, Lichtenstein P, Lucae S, MacIntyre DJ, Madden P, Magnusson PKE, Martin NG, McIntosh AM, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nyholt DR, Oskarsson H, Owen MJ, Padmanabhan S, Penninx BWJH, Pergadia ML, Porteous DJ, Potash JB, Preisig M, Rivera M, Shi J, Shyn SI, Sigurdsson E, Smit JH, Smith BH, Stefansson H, Stefansson K, Strohmaier J, Sullivan PF, Thomson P, Thorgeirsson TE, Van der Auwera S, Weissman MM, Breen G, Lewis CM
CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium
Biological psychiatry · 2017 · PMID 27519822 · open access

Questions about rs7647854

What is rs7647854?

rs7647854 is a single position in the genome, in or near the C3orf70 gene. Published research associates it with major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7647854 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs7647854 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7647854 come from?

GWAS Catalog, Biol Psychiatry 2016, PMID:27519822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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