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Cortical surface area

near PPP1R14BP5 · rs76470478

What the study found

Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.

The effect Each copy of the T allele shifted the measure 15.3 lower (95% confidence interval 10.56-20.03); p = 2 × 10−10.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6q22.32 — between genes, 34.4 kb from PPP1R14BP5.

What each result means

C/C No copy of the version the research linked to Cortical surface area. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cortical surface area. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cortical surface area. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs76470478

What is rs76470478?

rs76470478 is a single position in the genome, in or near the near PPP1R14BP5 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs76470478 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76470478 come from?

GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cortical surface area (rs76470478). MyGeneLog™. https://www.mygenelog.com/variants/rs76470478

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