Standard

Total lipids in medium HDL

near NRP1 · rs76444725

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs76444725 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs76444725 rs76444725 near NRP1

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 1 × 10−10.

Where it sits Chromosome 10, band 10p11.22 — between genes, 1.2 kb from NRP1.

What each result means

A/A Two copies of the version the research linked to Total lipids in medium HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Total lipids in medium HDL. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total lipids in medium HDL. This is the starting point the study compared everyone against.
Source

Questions about rs76444725

What is rs76444725?

rs76444725 is a single position in the genome, in or near the near NRP1 gene. Published research associates it with total lipids in medium hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76444725 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs76444725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76444725 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total lipids in medium HDL (rs76444725). MyGeneLog™. https://www.mygenelog.com/variants/rs76444725

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