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Male-pattern baldness

COPB2 · rs7642536

Where this position leads

Condition: Androgenetic Alopecia (Male Pattern Baldness)

rs7642536 Condition: Androgenetic Alopecia (Male Pattern Baldness) Androgenetic Alopecia (Male Pattern… Condition rs7642536 rs7642536 COPB2

What the study found

Who was studied 25,662 British ancestry cases, 17,928 British ancestry controls; replicated in 13,367 European ancestry cases, 11,851 European ancestry controls, 3,436 cases, 2,435 controls.

The effect Each copy of the T allele shifted the measure 0.2 higher (95% confidence interval 0.16-0.24); p = 2 × 10−21.

Where it sits Chromosome 3, band 3q23 — in an intron of MRPS22.

What each result means

C/C No copy of the version the research linked to Male-pattern baldness. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Male-pattern baldness. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Male-pattern baldness. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7642536

What is rs7642536?

rs7642536 is a single position in the genome, in or near the COPB2 gene. Published research associates it with male-pattern baldness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7642536 linked to?

On MyGeneLog this position is linked to Androgenetic Alopecia (Male Pattern Baldness). The research behind each link, and its sources, are set out on that condition page.

Does having rs7642536 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7642536 come from?

GWAS Catalog, Nat Commun 2017, PMID:29146897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Male-pattern baldness (rs7642536). MyGeneLog™. https://www.mygenelog.com/variants/rs7642536

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