IL23R · rs76418789
Where this position leads
Condition: Ulcerative Colitis
What the study found
Who was studied 705 Korean ancestry cases, 1,178 Korean ancestry controls; replicated in 980 Korean ancestry cases, 2,694 Korean ancestry controls.
The effect Each copy of the G allele carried 1.75 times the odds of Ulcerative colitis; p = 1 × 10−8.
How common The G allele had a frequency of about 93% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — a missense change in C1orf141.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2026-02-04.
ClinVar record 1167634 NM_144701.3(IL23R):c.445G>A (p.Gly149Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs76418789 is a single position in the genome, in or near the IL23R gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Inflamm Bowel Dis 2016, PMID:26398853. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Ulcerative colitis (rs76418789). MyGeneLog™. https://www.mygenelog.com/variants/rs76418789