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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 74,049 African American or Afro-Caribbean individuals, 37,043 Hispanic or Latin American individuals, 3,003 East Asian ancestry individuals, 275,068 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0284 higher (95% confidence interval 0.02-0.036); p = 4 × 10−12.
How common The C allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 11, band 11p15.4 — in an intron of SBF2.
What each result means
C/CTwo copies of the version the research linked to neutrophil (absolute count, minimum, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to neutrophil (absolute count, minimum, inv-norm transformed). That is a smaller link than two copies.
T/TNo copy of the version the research linked to neutrophil (absolute count, minimum, inv-norm transformed). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs76394996
What is rs76394996?
rs76394996 is a single position in the genome, in or near the SBF2 gene. Published research associates it with neutrophil (absolute count, minimum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs76394996 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76394996 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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