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Phosphatidylcholine levels

FADS2 · rs76368648

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,045 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.488 lower (95% confidence interval 0.34-0.64); p = 3 × 10⁻¹⁰.

Where it sits Chromosome 11, band 11q12.3 — between genes, 5.4 kb from RNU6-1243P.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Phosphatidylcholine levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phosphatidylcholine levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phosphatidylcholine levels compared to the general population.

Source

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N

and 16 more — show all

Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S

FinnGen Project

Nature communications · 2019 · PMID 31551469 · open access

Questions about rs76368648

What is rs76368648?

rs76368648 is a single position in the genome, in or near the FADS2 gene. Published research associates it with phosphatidylcholine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs76368648 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76368648 come from?

GWAS Catalog, Nature communications 2019, PMID:31551469. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Phosphatidylcholine levels (rs76368648). MyGeneLog™. https://www.mygenelog.com/variants/rs76368648

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