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Who was studied 329,821 European ancestry individuals; replicated in 122,867 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 7.59 lower; p = 3 × 10−14.
How common The A allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 3, band 3q22.3 — in an intron of STAG1.
What each result means
A/ATwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
rs7634476 is a single position in the genome, in or near the STAG1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7634476 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs7634476 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7634476 come from?
GWAS Catalog, Nature genetics 2018, PMID:29255261. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 152319Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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