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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 40,887 European ancestry cases, 327,689 European ancestry controls.
The effect
Each copy of the A allele carried 0.89 times the odds of Osteoarthritis of the hip or knee (with total joint replacement) (95% confidence interval 0.855546105-0.923869265); p = 2 × 10−9.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 9, band 9q22.32 — between genes, 42.1 kb from PTCH1.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis of the hip or knee (with total joint replacement). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Osteoarthritis of the hip or knee (with total joint replacement). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Osteoarthritis of the hip or knee (with total joint replacement). This is the starting point the study compared everyone against.
rs76340814 is a single position in the genome, in or near the near PTCH1 gene. Published research associates it with osteoarthritis of the hip or knee (with total joint replacement). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76340814 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs76340814 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76340814 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Osteoarthritis of the hip or knee (with total joint replacement) (rs76340814). MyGeneLog™. https://www.mygenelog.com/variants/rs76340814