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High blood pressure / hypertension

RYK · rs7633386

Where this position leads

Condition: Blood Pressure

rs7633386 Condition: Blood Pressure Blood Pressure Condition rs7633386 rs7633386 RYK

What the study found

Who was studied 38,518 African American or Afro-Caribbean cases, 16,987 African American or Afro-Caribbean controls, 16,330 Hispanic or Latin American cases, 12,984 Hispanic or Latin American controls, 2,059 East Asian ancestry cases, 1,488 East Asian ancestry controls, 191,352 European ancestry cases, 124,316 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0423 higher (95% confidence interval 0.03-0.054); p = 1 × 10−12.

How common The T allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 3, band 3q22.2 — in an intron of RYK.

What each result means

C/C No copy of the version the research linked to High blood pressure / hypertension. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to High blood pressure / hypertension. That is a smaller link than two copies.
T/T Two copies of the version the research linked to High blood pressure / hypertension. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs7633386

What is rs7633386?

rs7633386 is a single position in the genome, in or near the RYK gene. Published research associates it with high blood pressure / hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7633386 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs7633386 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7633386 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High blood pressure / hypertension (rs7633386). MyGeneLog™. https://www.mygenelog.com/variants/rs7633386

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