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Glucosuria (moderate to severe)

NEUROD1 · rs763092306

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 6,109 Icelandic ancestry cases, 135,512 Icelandic ancestry controls (includes non-array genotyped, whole-genome imputed individuals).

The effect Each copy of the T allele carried 23.74 times the odds of Glucosuria (moderate to severe) (95% confidence interval 9.04-62.36); p = 1 × 10−10.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 2, band 2q31.3 — a missense change in CERKL.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Glucosuria (moderate to severe) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glucosuria (moderate to severe).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glucosuria (moderate to severe) compared to the general population.
Source
Sequence variants associating with urinary biomarkers
Benonisdottir S, Kristjansson RP, Oddsson A, Steinthorsdottir V, Mikaelsdottir E, Kehr B, Jensson BO, Arnadottir GA, Sulem G, Sveinbjornsson G, Kristmundsdottir S, Ivarsdottir EV
and 26 more — show all
Tragante V, Gunnarsson B, Runolfsdottir HL, Arthur JG, Deaton AM, Eyjolfsson GI, Davidsson OB, Asselbergs FW, Hreidarsson AB, Rafnar T, Thorleifsson G, Edvardsson V, Sigurdsson G, Helgadottir A, Halldorsson BV, Masson G, Holm H, Onundarson PT, Indridason OS, Benediktsson R, Palsson R, Gudbjartsson DF, Olafsson I, Thorsteinsdottir U, Sulem P, Stefansson K
Human molecular genetics · 2019 · PMID 30476138 · open access

Questions about rs763092306

What is rs763092306?

rs763092306 is a single position in the genome, in or near the NEUROD1 gene. Published research associates it with glucosuria (moderate to severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs763092306 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs763092306 come from?

GWAS Catalog, Hum Mol Genet 2019, PMID:30476138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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