Standard

Total testosterone levels

near ETS1 · rs76299412

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 230,454 European ancestry women.

The effect Each copy of the A allele shifted the measure 0.0349 higher (95% confidence interval 0.027-0.043); p = 2 × 10⁻²⁰.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 11, band 11q24.3 — between genes, 59.6 kb from ETS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total testosterone levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total testosterone levels.

G/G Published research associates this genotype with typical/baseline likelihood of Total testosterone levels — no copies of the reported risk allele.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs76299412

What is rs76299412?

rs76299412 is a single position in the genome, in or near the near ETS1 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs76299412 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76299412 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total testosterone levels (rs76299412). MyGeneLog™. https://www.mygenelog.com/variants/rs76299412

← See all variants