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Fibrinogen levels

FGG · rs76289367

Where this position leads

Condition: Fibrinogen and Blood Clotting

What the study found

Who was studied 120,246 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0263 higher; p = 2 × 10⁻⁷⁶.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 4, band 4q32.1 — between genes, 1.4 kb from LOC124900169.

What each result means

G/G Two copies of the version the research linked to Fibrinogen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Fibrinogen levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Fibrinogen levels. This is the starting point the study compared everyone against.

Source

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Trompet S

and 119 more — show all

Müller-Nurasyid M, Zhao JH, Brody JA, Kleber ME, Guo X, Wang JJ, Auer PL, Attia JR, Yanek LR, Ahluwalia TS, Lahti J, Venturini C, Tanaka T, Bielak LF, Joshi PK, Rocanin-Arjo A, Kolcic I, Navarro P, Rose LM, Oldmeadow C, Riess H, Mazur J, Basu S, Goel A, Yang Q, Ghanbari M, Willemsen G, Rumley A, Fiorillo E, de Craen AJ, Grotevendt A, Scott R, Taylor KD, Delgado GE, Yao J, Kifley A, Kooperberg C, Qayyum R, Lopez LM, Berentzen TL, Räikkönen K, Mangino M, Bandinelli S, Peyser PA, Wild S, Trégouët DA, Wright AF, Marten J, Zemunik T, Morrison AC, Sennblad B, Tofler G, de Maat MP, de Geus EJ, Lowe GD, Zoledziewska M, Sattar N, Binder H, Völker U, Waldenberger M, Khaw KT, Mcknight B, Huang J, Jenny NS, Holliday EG, Qi L, Mcevoy MG, Becker DM, Starr JM, Sarin AP, Hysi PG, Hernandez DG, Jhun MA, Campbell H, Hamsten A, Rivadeneira F, Mcardle WL, Slagboom PE, Zeller T, Koenig W, Psaty BM, Haritunians T, Liu J, Palotie A, Uitterlinden AG, Stott DJ, Hofman A, Franco OH, Polasek O, Rudan I, Morange PE, Wilson JF, Kardia SL, Ferrucci L, Spector TD, Eriksson JG, Hansen T, Deary IJ, Becker LC, Scott RJ, Mitchell P, März W, Wareham NJ, Peters A, Greinacher A, Wild PS, Jukema JW, Boomsma DI, Hayward C, Cucca F, Tracy R, Watkins H, Reiner AP, Folsom AR, Ridker PM, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A

Human molecular genetics · 2016 · PMID 26561523

Questions about rs76289367

What is rs76289367?

rs76289367 is a single position in the genome, in or near the FGG gene. Published research associates it with fibrinogen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76289367 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

Does having rs76289367 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76289367 come from?

GWAS Catalog, Hum Mol Genet 2015, PMID:26561523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fibrinogen levels (rs76289367). MyGeneLog™. https://www.mygenelog.com/variants/rs76289367

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