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Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0386 higher (95% confidence interval 0.027-0.051); p = 2 × 10−10.
Where it sits Chromosome 3, band 3q12.1 — between genes, 92.2 kb from COL8A1.
What each result means
G/GNo copy of the version the research linked to Diastolic blood pressure. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Diastolic blood pressure. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Diastolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40436827 · open access
Questions about rs76258360
What is rs76258360?
rs76258360 is a single position in the genome, in or near the near COL8A1 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76258360 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs76258360 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76258360 come from?
GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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