G6PD · rs762517
Where this position leads
Drugs: Dapsone, nitrofurantoin and other oxidising drugs, Primaquine and tafenoquine, Rasburicase
What the study found
Who was studied 749,391 European, East Asian, Hispanic, admixed African or South Asian ancestry men; replicated in 626 Arab ancestry men, 4,056 Asian ancestry men, 4,851 African ancestry men, 7,302 Hispanic men, 15,135 South Asian ancestry men, 17,511 African American men, 57,013 East Asian ancestry men, 65,334 European ancestry men.
The effect Each copy of the A allele shifted the measure 0.0512 lower (95% confidence interval 0.039-0.063); p = 8 × 10−18.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome X, band Xq28 — in an intron of G6PD.
rs762517 is a single position in the genome, in or near the G6PD gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
G6PD carries pharmacogenomic findings for Dapsone, nitrofurantoin and other oxidising drugs, Primaquine and tafenoquine, Rasburicase. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genome biology 2022, PMID:36575460. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (rs762517). MyGeneLog™. https://www.mygenelog.com/variants/rs762517