Standard

Educational attainment (years of education)

MAML3 · rs76241605

Where this position leads

Condition: Educational Attainment

rs76241605 Condition: Educational Attainment Educational Attainment Condition rs76241605 rs76241605 MAML3

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied up to 1,131,881 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0139 higher (95% confidence interval 0.0096-0.0182); p = 6 × 10−10.

How common The A allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 4, band 4q31.1 — in an intron of MAML3.

What each result means

A/A Two copies of the version the research linked to Educational attainment (years of education). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Educational attainment (years of education). That is a smaller link than two copies.
G/G No copy of the version the research linked to Educational attainment (years of education). This is the starting point the study compared everyone against.
Source

Questions about rs76241605

What is rs76241605?

rs76241605 is a single position in the genome, in or near the MAML3 gene. Published research associates it with educational attainment (years of education). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76241605 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs76241605 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76241605 come from?

GWAS Catalog, Nature genetics 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Educational attainment (years of education) (rs76241605). MyGeneLog™. https://www.mygenelog.com/variants/rs76241605

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