Sensitive

Basal cell carcinoma

ST3GAL6 · rs7620634

Where this position leads

What the study found

Who was studied 31,787 European ancestry cases, 619,351 European ancestry controls.

The effect Each copy of the G allele carried 1.05 times the odds of Basal cell carcinoma (95% confidence interval 1.04-1.08); p = 9 × 10⁻⁹.

How common The G allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 3, band 3q12.1 — in an intron of ST3GAL6-AS1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Basal cell carcinoma — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Basal cell carcinoma.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Basal cell carcinoma compared to the general population.

Source

Combined analysis of keratinocyte cancers identifies novel genome-wide loci

Liyanage UE, Law MH, Han X, An J, Ong JS, Gharahkhani P, Gordon S, Neale RE, Olsen CM, MacGregor S, Whiteman DC

23andMe Research Team

Human molecular genetics · 2019 · PMID 31174203 · open access

Questions about rs7620634

What is rs7620634?

rs7620634 is a single position in the genome, in or near the ST3GAL6 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7620634 linked to?

On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs7620634 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7620634 come from?

GWAS Catalog, Hum Mol Genet 2019, PMID:31174203. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Basal cell carcinoma (rs7620634). MyGeneLog™. https://www.mygenelog.com/variants/rs7620634

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