Sensitive

Polycystic ovary syndrome (reproductive subtype)

IQCA1 · rs76182733

Where this position leads

Condition: Polycystic Ovary Syndrome

rs76182733 Condition: Polycystic Ovary Syndrome Polycystic Ovary Syndrome Condition rs76182733 rs76182733 IQCA1

What the study found

Who was studied 123 European ancestry cases, 2,964 European ancestry controls; replicated in 84 European ancestry cases, 1,134 European ancestry controls.

The effect Each copy of the G allele carried 5.68 times the odds of Polycystic ovary syndrome (reproductive subtype) (95% confidence interval 3.00-10.78); p = 3 × 10−9.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 2, band 2q37.3 — between genes, 10.5 kb from IQCA1.

What each result means

A/A No copy of the version the research linked to Polycystic ovary syndrome (reproductive subtype). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Polycystic ovary syndrome (reproductive subtype). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Polycystic ovary syndrome (reproductive subtype). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs76182733

What is rs76182733?

rs76182733 is a single position in the genome, in or near the IQCA1 gene. Published research associates it with polycystic ovary syndrome (reproductive subtype). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76182733 linked to?

On MyGeneLog this position is linked to Polycystic Ovary Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs76182733 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76182733 come from?

GWAS Catalog, PLoS Med 2020, PMID:32574161. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Polycystic ovary syndrome (reproductive subtype) (rs76182733). MyGeneLog™. https://www.mygenelog.com/variants/rs76182733

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