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Heart rate increase in response to exercise

SRRT · rs76181418

What the study found

Who was studied 5,4137 European ancestry individuals, 1,744 Asian ancestry individuals, 1,445 African ancestry individuals, 468 admixed individuals, 1,024 individuals.

The effect Each copy of the G allele shifted the measure 0.0616 higher (95% confidence interval 0.047-0.076); p = 3 × 10−16.

How common The G allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — between genes, 0.3 kb from ACHE.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart rate increase in response to exercise compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart rate increase in response to exercise.
T/T Published research associates this genotype with typical/baseline likelihood of Heart rate increase in response to exercise — no copies of the reported risk allele.
Source

Questions about rs76181418

What is rs76181418?

rs76181418 is a single position in the genome, in or near the SRRT gene. Published research associates it with heart rate increase in response to exercise. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs76181418 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76181418 come from?

GWAS Catalog, Nat Commun 2018, PMID:29497042. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart rate increase in response to exercise (rs76181418). MyGeneLog™. https://www.mygenelog.com/variants/rs76181418

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