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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 129,080 European ancestry cases, 473,524 European ancestry controls; replicated in 462,753 cases, 1,127,474 controls.
The effect
Each copy of the A allele shifted the measure 0.035 lower; p = 5 × 10−10.
How common The A allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 10, band 10q26.3 — in an intron of ADGRA1.
What each result means
A/ATwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
rs761777 is a single position in the genome, in or near the KNDC1 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs761777 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs761777 come from?
GWAS Catalog, Gut 2022, PMID:34187846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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