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Who was studied 16,677 South Asian ancestry cases, 33,856 South Asian ancestry controls; replicated in 157,384 European ancestry individuals.
The effect
Each copy of the C allele carried 1.40 times the odds of Type 2 diabetes (adjusted for BMI) (95% confidence interval 1.26-1.57); p = 1 × 10−9.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 13, band 13q31.1 — between genes, 27.8 kb from LINC00377.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes (adjusted for BMI). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes (adjusted for BMI). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes (adjusted for BMI). This is the starting point the study compared everyone against.
Communications biology · 2022 · PMID 35393509 · open access
Questions about rs76141923
What is rs76141923?
rs76141923 is a single position in the genome, in or near the near LINC00377 gene. Published research associates it with type 2 diabetes (adjusted for bmi). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76141923 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs76141923 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76141923 come from?
GWAS Catalog, Communications biology 2022, PMID:35393509. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (adjusted for BMI) (rs76141923). MyGeneLog™. https://www.mygenelog.com/variants/rs76141923