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Gut microbiota abundance (family Bifidobacteriaceae id.433)

ZRANB3 · rs7605229

Where this position leads

What the study found

Who was studied 14,306 European ancestry individuals, 811 Korean ancestry individuals, 1,097 Hispanic individuals, 114 African American individuals, 481 Middle Eastern ancestry individuals, 1,531 unknown and other admixed ancestry individuals.

The effect Each copy of the T allele shifted the measure 5.94 z score higher; p = 3 × 10⁻⁹.

Where it sits Chromosome 2, band 2q21.3 — in an intron of ZRANB3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Gut microbiota abundance (family Bifidobacteriaceae id.433) — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gut microbiota abundance (family Bifidobacteriaceae id.433).

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gut microbiota abundance (family Bifidobacteriaceae id.433) compared to the general population.

Source

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Bonder MJ

and 92 more — show all

Hansen TH, Frost F, Rühlemann MC, Turpin W, Moon JY, Kim HN, Lüll K, Barkan E, Shah SA, Fornage M, Szopinska-Tokov J, Wallen ZD, Borisevich D, Agreus L, Andreasson A, Bang C, Bedrani L, Bell JT, Bisgaard H, Boehnke M, Boomsma DI, Burk RD, Claringbould A, Croitoru K, Davies GE, van Duijn CM, Duijts L, Falony G, Fu J, van der Graaf A, Hansen T, Homuth G, Hughes DA, Ijzerman RG, Jackson MA, Jaddoe VWV, Joossens M, Jørgensen T, Keszthelyi D, Knight R, Laakso M, Laudes M, Launer LJ, Lieb W, Lusis AJ, Masclee AAM, Moll HA, Mujagic Z, Qibin Q, Rothschild D, Shin H, Sørensen SJ, Steves CJ, Thorsen J, Timpson NJ, Tito RY, Vieira-Silva S, Völker U, Völzke H, Võsa U, Wade KH, Walter S, Watanabe K, Weiss S, Weiss FU, Weissbrod O, Westra HJ, Willemsen G, Payami H, Jonkers DMAE, Arias Vasquez A, de Geus EJC, Meyer KA, Stokholm J, Segal E, Org E, Wijmenga C, Kim HL, Kaplan RC, Spector TD, Uitterlinden AG, Rivadeneira F, Franke A, Lerch MM, Franke L, Sanna S, D'Amato M, Pedersen O, Paterson AD, Kraaij R, Raes J, Zhernakova A

Nature genetics · 2021 · PMID 33462485

Questions about rs7605229

What is rs7605229?

rs7605229 is a single position in the genome, in or near the ZRANB3 gene. Published research associates it with gut microbiota abundance (family bifidobacteriaceae id.433). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7605229 linked to?

On MyGeneLog this position is linked to Gut Microbiota. The research behind each link, and its sources, are set out on that condition page.

Does having rs7605229 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7605229 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462485. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gut microbiota abundance (family Bifidobacteriaceae id.433) (rs7605229). MyGeneLog™. https://www.mygenelog.com/variants/rs7605229

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