Gene Knowledge Graph
UTC
Sensitive

Multiple sclerosis

NCF4 · rs760517

Where this position leads

Condition: Multiple Sclerosis

rs760517 Condition: Multiple Sclerosis Multiple Sclerosis Condition rs760517 rs760517 NCF4

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Multiple sclerosis compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Multiple sclerosis.
T/T Published research associates this genotype with typical/baseline likelihood of Multiple sclerosis — no copies of the reported risk allele.
Source
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium
Science (New York, N.Y.) · 2019 · PMID 31604244

Questions about rs760517

What is rs760517?

rs760517 is a single position in the genome, in or near the NCF4 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs760517 linked to?

On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs760517 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs760517 come from?

GWAS Catalog, Science 2019, PMID:31604244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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