Sensitive

Graves' disease

B3GALT4 · rs759916207

Where this position leads

Condition: Graves' Disease

rs759916207 Condition: Graves' Disease Graves' Disease Condition rs759916207 rs759916207 B3GALT4

What the study found

Who was studied 18,719 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,441,938 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.

The effect Each copy of the A allele shifted the measure 0.681 higher (95% confidence interval 0.56-0.8); p = 3 × 10−28.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — inside B3GALT4.

What each result means

A/A Two copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
Source

Questions about rs759916207

What is rs759916207?

rs759916207 is a single position in the genome, in or near the B3GALT4 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs759916207 linked to?

On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs759916207 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs759916207 come from?

GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Graves' disease (rs759916207). MyGeneLog™. https://www.mygenelog.com/variants/rs759916207

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