Standard

Heel bone mineral density

TMEM135 · rs75937733

Where this position leads

Condition: Heel Bone Mineral Density

rs75937733 Condition: Heel Bone Mineral Density Heel Bone Mineral Density Condition rs75937733 rs75937733 TMEM135

What the study found

Who was studied 426,824 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0331 lower (95% confidence interval 0.026-0.04); p = 1 × 10−20.

How common The A allele had a frequency of about 92% in the people studied.

Where it sits Chromosome 11, band 11q14.2 — in an intron of TMEM135.

What each result means

A/A Two copies of the version the research linked to Heel bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Heel bone mineral density. That is a smaller link than two copies.
G/G No copy of the version the research linked to Heel bone mineral density. This is the starting point the study compared everyone against.
Source

Questions about rs75937733

What is rs75937733?

rs75937733 is a single position in the genome, in or near the TMEM135 gene. Published research associates it with heel bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75937733 linked to?

On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

Does having rs75937733 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75937733 come from?

GWAS Catalog, Nat Genet 2018, PMID:30598549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heel bone mineral density (rs75937733). MyGeneLog™. https://www.mygenelog.com/variants/rs75937733

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